Literature summary extracted from
Yang, H.; Wang, Y.; Li, Y.; Zhang, L.; Deng, Y.; Qi, D.; Li, Y.; Li, W.
Roles of matrix metalloproteinase-26 in the growth, invasion and angiogenesis of breast cancer (2012), Oncol. Lett., 4, 832-836.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.4.24.B7 |
transfection of MCF-7 cells |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.24.B7 |
Homo sapiens |
Q9NRE1 |
- |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.4.24.B7 |
physiological function |
MMP26-transfected MCF-7 cells demonstrate increased atypia, including unusual mitotic figures, glucogen pools and special lysosomes in the cytoplasm. The adherence and spreading ability of MMP26-transfected cells are significantly increased compared with cells in the control group. The migration and invasion ability of MMP26-transfected cells is dramatically accelerated compared with the control group, but markedly reduced in the presence of anti-MMP26 antibody. MMP26 also increases the malignant phenotype in vivo. The number of vessel branches and the total length of vessels induced by MMP26-transfected cells are significantly increased compared to those induced by nontransfected cells |
Homo sapiens |